Genotoxic and cytotoxic effects of polyethylene microplastics on human peripheral blood lymphocytes

H Çobanoğlu, M Belivermiş, E Sıkdokur, Ö Kılıç… - Chemosphere, 2021 - Elsevier
… be crucial for human health. We aimed to determine the genotoxic and cytotoxic effects of
microplastic (MPs,10-45 μm, polyethylene) on human peripheral lymphocytes by using the …

Targeting natural killer cells in solid tumors

G Habif, A Crinier, P André, E Vivier… - Cellular & molecular …, 2019 - nature.com
… In human peripheral blood, NK cells are defined as CD14 − CD19 − CD3 − and can be … 1
(KLRG1), cytotoxic T lymphocyte antigen 4 (CTLA4) and lymphocyte activation gene 3 protein (…

Prognostic value of peripheral blood natural killer cells in colorectal cancer

Y Tang, M Xie, K Li, J Li, Z Cai, B Hu - BMC gastroenterology, 2020 - Springer
… The association between natural killer (NK) cells and survival in … aimed to clarify the
prognostic value of peripheral blood NK … The NK cells are the cytotoxic lymphocytes of the innate …

[HTML][HTML] Sugar free: novel immunotherapeutic approaches targeting siglecs and sialic acids to enhance natural killer cell cytotoxicity against cancer

J Daly, M Carlsten, M O'Dwyer - Frontiers in immunology, 2019 - frontiersin.org
Natural Killer (NK) cells are cytotoxic lymphocytes that play a key role in the immune system,
targeting … healthy donor-derived peripheral blood-NK (PB-NK) cell-mediated cytotoxicity (38)…

[HTML][HTML] Natural killer cells: potential biomarkers and therapeutic target in autoimmune diseases?

E Gianchecchi, DV Delfino, A Fierabracci - Frontiers in immunology, 2021 - frontiersin.org
… the peripheral blood and the liver of patients and associated with increased NK cell cytotoxic
… As opposed to T lymphocytes and other adaptive immune cells, NK cells do not need prior …

TNF-α-induced Tim-3 expression marks the dysfunction of infiltrating natural killer cells in human esophageal cancer

Y Zheng, Y Li, J Lian, H Yang, F Li, S Zhao, Y Qi… - Journal of translational …, 2019 - Springer
peripheral blood and tumor samples from 53 patients with esophageal cancer. Peripheral
and tumor-infiltrating NK cells were … aimed at restoring anti-tumor activity of T lymphocytes has …

Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders

NA Maskalenko, D Zhigarev… - Nature reviews Drug …, 2022 - nature.com
… In addition, NK cells can be triggered by cells targeted by IgG … of human peripheral blood
mononuclear cells with IL-2 was found to expand cytotoxic cells, which were named lymphocyte

[HTML][HTML] Role of decidual natural killer cells in human pregnancy and related pregnancy complications

X Zhang, H Wei - Frontiers in immunology, 2021 - frontiersin.org
… , NK cells represent up to 50–70% of decidua lymphocytes. … This review is focused on the
role of dNK cells in normal … of NKp46 + NK cells in the peripheral blood of women with PE …

[HTML][HTML] Targeting natural killer cells for tumor immunotherapy

C Zhang, Y Hu, C Shi - Frontiers in immunology, 2020 - frontiersin.org
… The important innate cytotoxic lymphocytes, natural killer (NK) cells, show … cells with enhanced
cytotoxic activity (66). Notably, pre-activation of human peripheral blood-derived NK cells (…

PD-1+ natural killer cells in human non-small cell lung cancer can be activated by PD-1/PD-L1 blockade

MP Trefny, M Kaiser, MA Stanczak, P Herzig… - Cancer Immunology …, 2020 - Springer
human blood cells and tumor-infiltrating lymphocytes Human peripheral blood mononuclear
cells (… Here, we aimed to obtain a broader overview of the expression of activating and …